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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K3
All Species:
9.39
Human Site:
S28
Identified Species:
17.22
UniProt:
P46734
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46734
NP_002747.2
347
39318
S28
R
K
K
D
L
R
I
S
C
M
S
K
P
P
A
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
A32
S
A
E
T
N
L
E
A
L
Q
K
K
L
E
E
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_546666
347
39324
S28
R
K
K
D
L
R
I
S
C
M
S
K
P
P
V
Cat
Felis silvestris
Mouse
Mus musculus
O09110
347
39278
S28
R
K
K
D
L
R
I
S
C
V
S
K
P
P
V
Rat
Rattus norvegicus
Q4KSH7
419
47517
P84
L
P
S
T
L
F
T
P
R
S
M
E
S
I
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511595
352
40240
I33
K
K
R
K
D
L
K
I
V
T
I
K
P
P
V
Chicken
Gallus gallus
Q90891
398
44059
D34
S
A
E
A
N
L
V
D
L
Q
K
K
L
E
E
Frog
Xenopus laevis
Q07192
446
50082
E113
A
K
A
L
S
T
N
E
Q
A
T
K
N
R
L
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
K44
P
K
E
L
K
L
P
K
E
V
F
E
K
P
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477162
334
38176
P23
P
E
A
A
I
V
P
P
R
N
L
D
S
R
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
N30
R
P
T
S
L
S
V
N
G
N
E
K
T
L
P
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
D34
T
A
S
G
T
F
H
D
G
D
F
L
L
N
Q
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
Y324
L
F
A
N
F
S
K
Y
V
D
I
K
S
G
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
30.7
N.A.
99.1
N.A.
96.5
37.2
N.A.
89.7
30.3
42.1
75.3
N.A.
57
N.A.
37.7
N.A.
Protein Similarity:
100
47
N.A.
99.7
N.A.
98.8
56.7
N.A.
93.1
48.7
58
84.4
N.A.
72.9
N.A.
55.6
N.A.
P-Site Identity:
100
6.6
N.A.
93.3
N.A.
86.6
6.6
N.A.
26.6
6.6
13.3
20
N.A.
6.6
N.A.
20
N.A.
P-Site Similarity:
100
20
N.A.
93.3
N.A.
93.3
13.3
N.A.
40
20
20
40
N.A.
20
N.A.
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.7
23.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.2
35.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
24
24
16
0
0
0
8
0
8
0
0
0
0
24
% A
% Cys:
0
0
0
0
0
0
0
0
24
0
0
0
0
0
0
% C
% Asp:
0
0
0
24
8
0
0
16
0
16
0
8
0
0
0
% D
% Glu:
0
8
24
0
0
0
8
8
8
0
8
16
0
16
24
% E
% Phe:
0
8
0
0
8
16
0
0
0
0
16
0
0
0
0
% F
% Gly:
0
0
0
8
0
0
0
0
16
0
0
0
0
8
0
% G
% His:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
8
0
24
8
0
0
16
0
0
8
0
% I
% Lys:
8
47
24
8
8
0
16
8
0
0
16
70
8
0
0
% K
% Leu:
16
0
0
16
39
31
0
0
16
0
8
8
24
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
16
8
0
0
0
0
% M
% Asn:
0
0
0
8
16
0
8
8
0
16
0
0
8
8
0
% N
% Pro:
16
16
0
0
0
0
16
16
0
0
0
0
31
39
8
% P
% Gln:
0
0
0
0
0
0
0
0
8
16
0
0
0
0
8
% Q
% Arg:
31
0
8
0
0
24
0
0
16
0
0
0
0
16
0
% R
% Ser:
16
0
16
8
8
16
0
24
0
8
24
0
24
0
8
% S
% Thr:
8
0
8
16
8
8
8
0
0
8
8
0
8
0
0
% T
% Val:
0
0
0
0
0
8
16
0
16
16
0
0
0
0
24
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _